How to live long and healthy

WHY AGING BADLY COSTS
Aging badly costs, both in human terms, for those directly concerned, and for the state due to the increase in expenditure related to chronic diseases, hospitalizations and drugs. And with the prospect of a progressive aging of the population (it is estimated that in 2050, 1 out of 3 Italians will be over 65), prevention is very important and topical.

OVERWEIGHT AS A RISK FACTOR
Visceral (abdominal) obesity in particular is associated with cardio-metabolic risk factors such as type 2 diabetes, inflammation, dyslipidemia, hypertension, heart failure, stroke, vascular dementia, but also with NASH (non-alcoholic steatohepatitis) and a series of tumors (colon, breast, uterus, kidney, esophagus, pancreas, liver). It must be remembered that even sleeping poorly, poorly and in a fragmented way has a very powerful effect in modulating the risk of obesity, through the modification of leptin and ghrelin.

PATHOLOGIES AND AGING DO NOT START AT 65 YEARS
The most common chronic diseases share a common metabolic-molecular substrate: many of the metabolic-molecular factors that underlie the onset of the most common forms of cancer, in some way have to do with fatty liver, vascular dementia and probably with Alzheimer’s, heart failure, heart attack, hypertensive diabetic nephropathy and many other pathologies.

And this metabolic-molecular pabulum can be significantly modified by lifestyles (diet, smoking, physical activity, stress). It is important to understand that pathologies and aging do not begin at 65. The metabolic-molecular accumulation of damage begins in the uterus and perhaps even before conception. Parents’ lifestyles can change the so-called epigenome (ie how our genes are ‘read’, not their content).

It is therefore necessary to intervene from before conception to slow down the accumulation of molecular metabolic damage. The watchword is therefore to act on the signaling pathways of aging, to move from the disease-centered approach, which is economically unsustainable, to the prevention-centered one, based on the personalized prescription of targeted interventions that block or slow down the accumulation of damage. metabolic-molecular. The signaling pathways of aging can be effectively inhibited through diet and physical activity.

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